Mechanism:

  • Rs8179183 is in the leptin receptor LEPR gene [R].

  • LEPR is associated with insulin resistance which is a key feature of metabolic syndrome [R1].

​​The Minor "C" allele is associated with:

  • CC= Increased likelihood to gain weight in response to treatment with antipsychotic risperidone [R]. 

  • The CC allele when taking risperidone has a normal effect on weight, while the CG and GG allele lead to lower likelihood to gain weight when taking risperidone [R]

  • Increased insulin resistance and metabolic syndrome in adults when interacting with unsaturated fatty acids [R].

  • Increased fat mass index in children within the lower ponderal index on total fat content [R2].

  • Possible increased sensitivity to nervous damage (spina bifida) [R3].

  • Significant change in body fat through dieting via low carb diets or low-fat diets [R4]  

  • More frequent in HELLP syndrome (high blood pressure in pregnant women, the rupture of red blood cells, high liver enzymes, and low platelet level) [R5].

  • Increased susceptibility to a parasitic infection (E.histolytica), this explains the differences in the parasitic sensitivity from child to child [R6].

The Major "G" allele is associated with:

  • Decreased likelihood to gain significant weight compared to the CC in Caucasians [R]

No correlation:

  • No correlation between aerobic fitness and this SNP [R7].

  • No significant association between this SNP and breast cancer [R7].

  • No differences in eating behaviors (i.e. eating uncontrollably or emotionally) or in body mass index due to this SNP [R8].

rs8179183

Parent Gene: LEPR

Importance: 3
Less common allele: C = 14%
More common allele: G = 86%
My Genotype: Log In