rs8176927 is a SNP of the GPX3 gene, and is significantly associated with cancer (thyroid and stomach).

The ''C'' allele confers an increased risk effect for differentiated thyroid cancer (DTC).  An individual carrying the TC genotype in the older group had an increased risk of DTC than controls (OR = 1.73, P = .037) [R].

The ''C'' allele was significantly overtransmitted to affected  arteriopathy stroke (AS) children (P = 0.019), but not to affected thromboembolic stroke (TS) children (P = 0.34). The corresponding CC haplotype was also significantly overtransmitted to AS children (P= 0.03), but not to TS children or in children with cerebral sinovenous thrombosis (CSVT) [R].



Parent Gene: GPX3

Importance: 2
Less common allele: C = 16%
More common allele: T = 84%
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