Mechanism

Decreased ability to repair or destory damaged DNA. (AA) [R]

Normal ability to repair or destory damaged DNA. (C) [R]

The Minor allele “A” is associated with:

  • Increased risk of colon cancer (AA). [R]

  • Increased risk for developing breast and ovarian cancer (AA). [R]

    • Only associated with African Americans.

The Major allele “C” is associated with:

  • Normal risk of colon cancer (CC and CA). [R]

  • Normal risk for developing breast and ovarian cancer (CC and CA). [R]

    • This also includes AA genotype for European Americans.

rs8176318

Parent Gene: BRCA1

Importance: 3
Less common allele: A = 32%
More common allele: C = 68%
My Genotype: Log In