This SNP is in the promoter region of CNR1 [R].
The T allele is assoicated with lower extraversion and lower conscientiousness [R].
The T allele is associated with Headache w/ Nausea in the presence of life stress [R].
Males with CC had higher abstinence rates from smoking when given a nicotine spray compared to those with at least one minor allele. Opposite and variable effects of these SNPs in females may be attributed to gender differences in the pharmacological effects of nicotine [R].