Mechanisms:

This gene results in functional changes of the receptor in cells [R].

  • Higher levels of binding to nicotinic acetylcholine receptors (AA) [R].
  • Increased levels of receptor binding (A) [R].
  • Normal levels of nicotinic acetylcholine receptor binding (G) [R].

The G (minor) allele is associated with: 

  • Addiction to tobacco and smoking [R] [R].

  •  Early tobacco addiction [R].(G allele likely)

  • Decreased ability to stop smoking [R].

The A (major) allele is associated with:

  • Decreased maximal response to a nicotine activator [R].
  • Increased nicotine dependence [R] and propensity to smoke [R].
  • Increased risk of lung cancer in both smokers and nonsmokers (not statistically significant in nonsmokers) [R][R][R].
  • Increased cigarette consumption of 0.9 cigarettes per day [R] and 1 year increased time of smoking (42 vs. 43) [R].
  • Greater cancer-causing nitrosamine extraction per cigarette dose [R].
  • Increased risk of tumors developing in squamous cells and epithelial tissue in the lungs [R].
  • Increased unregulated cell division and programmed cell death [R].

This Gene:

  • Influences early tobacco addiction [R].
  • Influences the ability to stop smoking [R].

rs8042374

Parent Gene: CHRNA3

Importance: 3
Less common allele: G = 45%
More common allele: A = 55%
My Genotype: Log In
Risk Allele: A, A, A, A

Disease/Trait: Lung Carcinoma

rs8042374 is associated with Lung Carcinoma (R) . It is reported to association with Lung cancer. No specific risk allele was identified in the study.

Disease/Trait: Schizophrenia

The A allele of rs8042374 is reported to be associated with Schizophrenia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Schizophrenia.

Disease/Trait: Schizophrenia

The A allele of rs8042374 is reported to be associated with Schizophrenia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Schizophrenia.

Disease/Trait: Fev/Fec Ratio

The A allele of rs8042374 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The A allele of rs8042374 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Forced Expiratory Volume

The A allele of rs8042374 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The A allele of rs8042374 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.