Mechanism

  • Decreased ability to repair or destroy damaged DNA in some cell types. (AA)  [R]
  • Normal ability to repair or destroy damaged DNA in some cell types.  (G) [R]

The Minor allele “A” is associated with:

  • Increased risk for developing breast cancer (AA). [R]

  • Women with a Body Mass Index (BMI) greater than 25% have significantly increased risk of developing non-Hodgkin Lymphoma (NHL) (AA and AG). [R]

  • Decreased risk of cervical cancer (AA). [R]

  • Normal risk for developing esophageal squamous cell carcinoma (ESCC). [R]

The Major allele “G” is associated with:

  • Normal risk for developing breast cancer (GG and GA). [R]

  • Women with a Body Mass Index (BMI) lower than 25% have a normal risk of developing non-Hodgkin Lymphoma (NHL) (AA and AG and GG). [R]

  • Normal risk of cervical cancer (GG and GA). [R]

  • Increased risk for developing esophageal squamous cell carcinoma (ESCC). [R]

rs799917

Parent Gene: BRCA1

Importance: 4
Less common allele: G = 46%
More common allele: A = 54%
My Genotype: Log In