The "C" (minor) allele is associated with:

  • CC= presumably results in better vitamin D receptor function.
  • CC= higher bone mass and better bone structure (R).
  • 37% decreased risk of Parkinson's in a population of hispanics who were exposed to more sun (R).
  • Increased protection against asthma in the Chinese (one or two Cs) (R).
  • 1.6X increased susceptibility for lung cancer in smokers carrying a C (R).

The "A" (major) allele is associated with:

  • The AA= Significantly increased risk of gum disease in non-smokers (R).
  • AA= Increased protection from Thyroid cancer (follicular carcinoma) (R).

Summary

CC results in a higher bone mass and better bone structure (R).

CC (minor allele) genotype was associated with a 37% decreased risk of Parkinson's in a population of hispanics who were exposed to more sun (R).

One or more C's (minor alleles) was protective against asthma in the Chinese (R).

Smokers carrying the variant C allele were 1.6X more susceptible to lung cancer (R).

The AA genotype who had ever smoked had a significantly increased risk of gum disease (R).

AA confers protection from Thyroid cancer (follicular carcinoma) (R).

(an intronic C→A replacement.....A=A, C = a) (RR2)..

rs7975232

Parent Gene: VDR

Importance: 4
Less common allele: C = 48%
More common allele: A = 52%
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