Each minor allele at rs795484 (guanine [G]>adenine [A]) contributed +17.6 μg/kg (95% confidence interval [CI] 10.7-24.4) to dose. Effect direction and magnitude were replicated in an independent cohort of 75 EC children (P<0.05). No association with morphine dose was detected in African Americans (AA) (n=241). Postoperative pain scores ⥠7/10 were associated with rs795484 (G>A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01).

[PMID 24909733]


Parent Gene: TAOK3

Importance: 3
Less common allele: T = 27%
More common allele: C = 73%
My Genotype: Log In
Risk Allele: A

Disease/Trait: Response To Morphine

The A allele of rs795484 is reported to be associated with Response To Morphine (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Morphine dose requirement in tonsillectomy and adenoidectomy surgery (EA).