rs7775 (R324G) osteoarthritis at multiple joints (p = 0.07), particularly in the hip in women [PMID 17237116]

associated with osteoarthritis of the hip in females

This is an arg324-to-gly (R324G) substitution

[PMID 19479880] Meta-analysis of 14 studies did not support a significant association between rs7775 and osteoarthritis.


[PMID 22095095] Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis




[PMID 15210948] Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

[PMID 18787887] Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.

[PMID 20043861] No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.

[PMID 22544526] Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.




[PMID 23516639] Association of single nucleotide polymorphisms in wnt signaling pathway genes with breast cancer in saudi patients

rs7775

Parent Gene: FRZB

Importance: 1
Less common allele: C = 13%
More common allele: G = 87%
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