rs7775 (R324G) osteoarthritis at multiple joints (p = 0.07), particularly in the hip in women [PMID 17237116]
associated with osteoarthritis of the hip in females
This is an arg324-to-gly (R324G) substitution
[PMID 19479880] Meta-analysis of 14 studies did not support a significant association between rs7775 and osteoarthritis.
[PMID 22095095] Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis
[PMID 15210948] Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.
[PMID 18787887] Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
[PMID 20043861] No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
[PMID 22544526] Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.