rs7771980, also known as -1025T>C, is a SNP in the RUNX2 gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification.

This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus osteoporosis in several studies, but with different correlations.

In a study of 821 Spanish postmenopausal women, rs7771980(C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype.[PMID 17878995]

In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.[PMID 19424741]

[PMID 18357615] Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.


Parent Gene: RUNX2

Importance: 1
Less common allele: C = 8%
More common allele: T = 92%
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