rs7754561 was significantly associated with Type 2 diabetes (T2D) [R].

rs7754561 was significantly associated with birth weight (p = 0.0016), the ''AA'' homozygotes have the highest birth weight (3 748 g vs. 3 293 g and 3 206 g for AG and GG) [R]. 

Note: However, the association of the A allele with higher birth weight is biologically plausible because that allele is associated with lower production of ectonucleotide pyrophosphatase phosphodiesterase gene (ENPP1), which is expected to result in increased sensitivity to insulin, uptake of glucose, and promotion of fetal growth.

The ''G'' allele was positively associated with hypertriglyceridemia (OR 1.478; P = 0.002) [R].

The ''G'' allele was found to be associated with obesity in male, but not in female, subjects (P = 0.035) [R].

 

 

rs7754561

Parent Gene: ENPP1

Importance: 2
Less common allele: A = 44%
More common allele: G = 56%
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