HMMR is linked to early-onset breast cancer .

However, a more recent, larger European case-control study found no association between rs7712023 and risk of breast cancer .[PMID 19065580]

[PMID 19064580] breast cancer

  • rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9],
  • rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7],
  • rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1],
  • rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and
  • rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].

rs7712023

Parent Gene: HMMR

Importance: 1
Less common allele: T = 33%
More common allele: A = 67%
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