rs769449 is a SNP of the APOE gene. This SNP is

  • moderately associated with Cerebrospinal fluid (CSF) tau/ptau levels [R].
  • strongly associated with Low-density lipoprotein cholesterol (LDL-C) (P=4.7×10−7) [R].
  • associated with longevity [R].

rs769449 was also associated with cognitive decline among African-Americans (p = 0.005) [R].

 

rs769449

Parent Gene: APOE

Importance: 5
Less common allele: A = 6%
More common allele: G = 94%
My Genotype: Log In
Risk Allele: A, A, A, A, A

Disease/Trait: Alzheimer's Disease Biomarker Measurement

The A allele of rs769449 is reported to be associated with Alzheimer's Disease Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal P-tau181p levels.

Disease/Trait: Cerebrospinal Fluid Biomarker Measurement

The A allele of rs769449 is reported to be associated with Cerebrospinal Fluid Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal P-tau181p levels.

Disease/Trait: P-Tau Measurement

The A allele of rs769449 is reported to be associated with P-tau Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal P-tau181p levels.

Disease/Trait: T-Tau Measurement

The A allele of rs769449 is reported to be associated with T-tau Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal T-tau levels.

Disease/Trait: Alzheimer's Disease Biomarker Measurement

The A allele of rs769449 is reported to be associated with Alzheimer's Disease Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal T-tau levels.

Disease/Trait: Cerebrospinal Fluid Biomarker Measurement

The A allele of rs769449 is reported to be associated with Cerebrospinal Fluid Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal T-tau levels.

Disease/Trait: Alzheimer's Disease Biomarker Measurement

The A allele of rs769449 is reported to be associated with Alzheimer's Disease Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal fluid AB1-42 levels.

Disease/Trait: Cerebrospinal Fluid Biomarker Measurement

The A allele of rs769449 is reported to be associated with Cerebrospinal Fluid Biomarker Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal fluid AB1-42 levels.

Disease/Trait: Beta-Amyloid 1-42 Measurement

The A allele of rs769449 is reported to be associated with Beta-amyloid 1-42 Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebrospinal fluid AB1-42 levels.

Disease/Trait: Cerebrospinal Fluid Biomarker Measurement

rs769449 is associated with Cerebrospinal Fluid Biomarker Measurement (R) . It is reported to association with Cerebrospinal fluid biomarker levels Apolipoprotein E (isoform E2). No specific risk allele was identified in the study.

Disease/Trait: Parental Longevity

rs769449 is associated with Parental Longevity . It is reported to have a 0.058580999999999994 unit increase on Parental longevity (combined parental age at death). No specific risk allele was identified in the study.

Disease/Trait: Alzheimers Disease

The A allele of rs769449 is reported to be associated with Alzheimers Disease . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (ptau).

Disease/Trait: P-Tau Measurement

The A allele of rs769449 is reported to be associated with P-tau Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (ptau).

Disease/Trait: T-Tau Measurement

The A allele of rs769449 is reported to be associated with T-tau Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (tau).

Disease/Trait: Alzheimers Disease

The A allele of rs769449 is reported to be associated with Alzheimers Disease . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (tau).

Disease/Trait: Cingulate Cortex Measurement

rs769449 is associated with Cingulate Cortex Measurement (R) . It is reported to association with Cingulate cortical amyloid beta load. No specific risk allele was identified in the study.

Disease/Trait: Amyloid-Beta Measurement

rs769449 is associated with Amyloid-beta Measurement (R) . It is reported to association with Cingulate cortical amyloid beta load. No specific risk allele was identified in the study.

Disease/Trait: Cognitive Decline

rs769449 is associated with Cognitive Decline (R) . It is reported to have a 0.0315 unit decrease on Cognitive decline (age-related) (EA). No specific risk allele was identified in the study.

Disease/Trait: C-Reactive Protein Measurement

rs769449 is associated with C-reactive Protein Measurement . It is reported to have a 0.26 mg/dl decrease on C-reactive protein. No specific risk allele was identified in the study.