The Minor "C" allele is associated with:
- More subcutaneous fat (second and third lumbar vertebrae [L2/3]) at baseline (p=0.04) (R).
- Higher percentage of subcutaneous fat with resistance training [R]
- Slightly higher BMI than G allele carriers in a meta-analysis study of 16,969 individuals (p=0.046) (CC) (R).
- With an exercise intervention, CC homozygotes had lost, on average, 1.7 kg more weight at 1 year after randomization than G allele carriers (R).
- Increased obesity risk was found in a meta-analysis study revealed (P=0.035), but a decreased obesity risk in population-based studies with subjects selected for better health status (P=0.028) (CC) (R).