The Minor "C" allele is associated with:

  • More subcutaneous fat (second and third lumbar vertebrae [L2/3]) at baseline (p=0.04) (R).
  • Higher percentage of subcutaneous fat with resistance training [R]
  • Slightly higher BMI than G allele carriers in a meta-analysis study of 16,969 individuals (p=0.046) (CC) (R).
  • With an exercise intervention, CC homozygotes had lost, on average, 1.7 kg more weight at 1 year after randomization than G allele carriers (R).
  • Increased obesity risk was found in a meta-analysis study revealed (P=0.035), but a decreased obesity risk in population-based studies with subjects selected for better health status (P=0.028) (CC) (R).


Parent Gene: INSIG2

Importance: 3
Less common allele: C = 29%
More common allele: G = 71%
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