rs749292 is a SNP of the CYP19A1 gene. It is significantly associated with metabolic disorders.
In letrozole-treated patients, rs749292 was significantly associated with decreases in triglycerides by 20.2 mg/dL and 39.3 mg/dL (P < 0.00053), respectively, and with variable changes in high-density lipoprotein (HDL-C) from decreases by 4.2 mg/dL to increases by 9.8 mg/dL (P < 0.00053) [R].
The ''A'' allele was positively associated with ovarian cancer risk in a codominant model for all races combined (AG versus AA genotype: odds ratio (OR), 1.48; GG versus AA: OR, 1.8; P(trend)=0.002) [R].
Carrying the ''A'' allele was associated with an increased risk of endometrial cancer (OR=1.14, P = 7.1 x 10(-7)) [R].
Women with the ''GG'' genotype had a higher mean score for cognitive functions [R].
The ''AA'' genotype was associated with a 2.3 kg/m2 lower BMI than the GA/GG genotype (P = 0.05) in pre and early perimenopausal women [R].