rs744154 is a SNP of the ERCC4 gene. It is marginally associated with a decreased risk of cancer.

rs744154 wa associated with a protective effect on bladder cancer risk.patients with the ''C'' allele had a shorter overall recurrence-free survival [R]. 

A marginally significant association of the ''G'' allele with breast cancer risk was seen for both BRCA1 (HR: 0.78, P=0.05) and BRCA2 (HR: 0.68, P=0.06) mutation carriers [RR].

The minor allele ''C'' was found to be associated with the exon 19 in-frame deletion in female never-smoking female lung adenocarcinoma patients but not in male never-smokers [R]. 

A significantly decreased risk of gastric cancer associated with the ''GC/CC'' genotypes (OR=0.56, P=0.003) compared with the wild-type ''GG'' genotype [R]. 


Parent Gene: ERCC4

Importance: 2
Less common allele: C = 22%
More common allele: G = 78%
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