The "C" allele is associated with:

  • Elevated cholesterol, based on a study of European patients with Metabolic Syndrome [R].

  • Increased risk of recurrent miscarriage in women with the CC genotype [R].

  • Increased exhaled levels of FeNO in asthmatic patients. The measure of FeNO  content in an individual’s exhaled breath is considered a representative of the degree of “eosinophilic inflammation”  which is an allergic inflammatory condition of the throat. [R]

The "T" allele is associated with:

  • Increased risk of nephropathy, kidney complications, in Diabetics with the the TT genotype [R].


Parent Gene: NOS3

Importance: 1
Less common allele: C = 23%
More common allele: T = 77%
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