rs733618 is a SNP in the CTLA4 gene. It is significantly associated with an increased risk of Myasthenia gravis (a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness).

T/C genotype was associated with a novel risk of Graves' disease (GD) (P=0.0096) [R].

Lymphatic filariasis (LF) carriers of the TC genotypes (p = 0.02) and those with combined minor allele C carriers (TC + CC; p = 0.01) exhibited a significantly decreased risk for LF [R].

The TT genotype was significantly overrepresented in patients with urinary schistosomiasis (p=0.001). Meanwhile, the TC genotype (p=0.001), was significantly decreased in the patients with schistosomiasis, as compared with the controls [R].

Patients experiencing early acute rejection (AR) were found to have a higher frequency of the TT genotype and T allele (p=0.000 and p=0.002, respectively) [R].




Parent Gene: CTLA4

Importance: 2
Less common allele: C = 17%
More common allele: T = 83%
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