Note: This SNP is located near the HRK (hara-kiri) and FBXW8 genes [R]. Interestingly, it also influences in the expression levels (transcription activity) of the TESC (tescalin) gene, despite not actually being located within the TESC gene itself [R, R].

This SNP also appears to interact closely with the RELN (reelin) gene SNP rs2299403 [R].

The 'T' allele of rs7294919 is associated with increased TESC gene levels [R, R].

The TESC gene suppresses the RELN gene [R]. One of RELN's functions is to promote neurogenesis. This means that high TESC gene levels may impair neurogenesis. This interaction probably explains why this SNP has been associated with neurogenesis, brain size (e.g. hippocampal volume), and even certain cognitive functions, such as verbal intelligence [R, R, R].

rs7294919

Parent Gene: FBXW8, HRK

Importance: 3
Less common allele: C = 21%
More common allele: T = 79%
My Genotype: Log In
Risk Allele: C, T

Disease/Trait: Hippocampal Volume

The C allele of rs7294919 is reported to be associated with Hippocampal Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Brain structure (Mean bilateral hippocampal volume).

Disease/Trait: Hippocampal Volume

The T allele of rs7294919 is reported to be associated with Hippocampal Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Hippocampal volume.

Disease/Trait: Hippocampal Volume

rs7294919 is associated with Hippocampal Volume (R) . It is reported to have a 48.84 unit decrease on Subcortical brain region volumes (Hippocampus, EA). No specific risk allele was identified in the study.