Mechanisms:

  • High CETP activity (G)

  • Low CETP activity (A)

The “A” allele is associated with:

  • Increased HDL levels [R]

  • Low risk of myocardial infarction [R]

  • High apolipoprotein concentrations [R]

  • Increased risk of gallbladder cancer (Chilean women) [R]

  • Increased risk of coronary artery disease [R]

  • Lower HDL concentrations in postmenopausal women [R]

  • Decreased risk of coronary atherosclerosis (Chinese) [R]

The “G” allele is associated with:

  • Decreased levels of HDL [R]

This SNP is associated with (unknown which alleles):

  • Protective effects of moderate alcohol consumption in terms of heart disease (men) [R]

Increased risk of type 2 diabetes [R]

rs708272

Parent Gene: CETP

Importance: 3
Less common allele: A = 38%
More common allele: G = 62%
My Genotype: Log In