This gene encodes for the vitamin D binding protein which inhibits the activity of vitamin D (1,25-dihydroxyvitamin D), as well as clearance of vitamin D metabolites from the circulation.

The protein product may be altered. It has been associated with Serum vitamin D-binding protein levels.

It was found that Vitamin D Binding Protein, free vitamin D and bioactive vitamin D were significantly associated with rs7041mutation.

Major "A" allele:

  • AA = better response to vitamin D [R].
  • AA = improved survival when supplementing with vitamin D, in patients with early-stage lung adenocarcinoma with lower 25(OH)D levels [R].
  • AA =  when given 2000 IU, people had higher levels of vitamin D at 6 and 12 months (p = 0.001, 0.023 respectively). At high dose (4000 IU), no significant effects were found [R].
  • AA = In ex-smokers, vitamin D levels were reduced by 25% (p<0.0001)
  • AA = increased risk for COPD (OR = 2.11, p=0.009). They conclude that since vitamin D deficiency occurs frequently in COPD and correlates with its severity, vitamin D supplementation may be warranted in patients with severe COPD, and especially in those carrying A alleles [R].
  • A = greater prevalence of moderate and severe depression when consuming a high protein, low fat diet [R].
  • A = associated with higher 25(OH)D levels in patients with CAP [R].
  • AA = Vitamin D Metabolite ratio (compared to vitamin D) was relatively lower compared to AA and AC genotype (p = 0.008) [R].
  • AA = decreased susceptibility of Hepatitis C Viral infection [R].

Minor C allele:

  • CC = Vitamin D Metabolite ratio (compared to vitamin D) was significantly higher compared to AA and AC genotype (p = 0.008) [R].
  • CC = lower prevalence of moderate and severe depression when consuming a high protein, low fat diet [R].
  • CC = associated with lower 25(OH)D levels in patients with CAP [R].
  • C alleles = increased susceptibility of Hepatitis C Viral infection [R].
  • CC/CA = higher 25OHD levels were associated with a lower risk of Multiple Sclerosis in whites [R].
  • CC/CA = less of a response to vitamin D [R].
  • CC/CA = less improved survival when supplementing with vitamin D, in patients with early-stage lung adenocarcinoma with lower 25(OH)D levels [R].
  • CC/CA =  when given 2000 IU, people had relatively lower levels of vitamin D at 6 and 12 months (p = 0.001, 0.023 respectively). At high dose (4000 IU), no significant effects were found [R].
  • CC/CA = In ex-smokers, vitamin D levels were relatively increased compared to AA.
  • CC/CA = decreased risk for COPD. They conclude that since vitamin D deficiency occurs frequently in COPD and correlates with its severity, vitamin D supplementation may be warranted in patients with severe COPD, and especially in those carrying A alleles [R].

rs7041

Parent Gene: GC, VDR

Importance: 5
Less common allele: C = 38%
More common allele: A = 62%
My Genotype: Log In
Risk Allele: T