rs700519 is linked to the CYP19A1 gene. It is significantly associated with breast cancer .

The age-adjusted hazard ratios (HR) for the A/A genotype was 2.2 for overall survival and 2.1 for disease-free survival in breast cancer patients, compared with those carrying the ''G'' allele [R].

Genotype AA+AG alone or in combination were significantly associated with decreased risk of endometriosis [R].

Polycystic ovary syndrome (PCOS) patients showed a lower frequency of the T allele and TT homozygocity than healthy controls (P = 0.019; genotype P = 0.004) [R].

The minor allele ''A'' homozygotes were associated with both overall survival and disease-free survival from breast cancer [R].


Parent Gene: CYP19A1

Importance: 2
Less common allele: A = 14%
More common allele: G = 86%
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