rs6948 is a SNP of the CASP3 gene. It may influence the expression of CASP3 and is associated with severe hematologic toxicity risk.
rs6948 (no reported alleles) was associated with a decreased risk for non-Hodgkin lymphoma (NHL), particularly follicular lymphoma (OR (CC+TC) = 0.4) [R].
The incidence of severe hematologic toxicity was significantly lower in ''G'' allele carriers (P = 0.005; odds ratio = 0.524) [R].
Compared to individuals with the ''TT'' genotype subjects with the ''GG'' genotype had a five-fold decreased risk of multiple myeloma (odds ratio (OR)(CC) = 0.2) [R].