rs6917 is a SNP of the PHB gene. It may play a role in prohibitin (PHB) transcriptional regulation.

The ''A'' allele was reported to be associated with significantly increased risk of breast cancer in women aged less than 50 years who had a first-degree relative with breast cancer [R].

The minor allele ''A'' is associated with increased susceptibility to breast cancer . The homozygote codominant model TT versus CC (OR 1.47), and the recessive model TT versus CC/CT (OR 1.45) [R].

The presence of the ''A'' allele was associated with reduced PHB expression in gastric cancer (GC) (P<0.001) [R].

 

rs6917

Parent Gene: PHB

Importance: 2
Less common allele: A = 17%
More common allele: G = 83%
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