rs689465 is a SNP in the PTGS2 gene, also known as COX-2, that has been associated with increased risk for mild asthma based on a study of 663 Australian patients. The odds ratio for mild asthma associated with (A;A) genotypes was 1.5 (CI: 1.12-2.02, p=0.02).[PMID 18489027]
[PMID 21304218] Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.
[PMID 21538574] Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.
[PMID 21848701] Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.
[PMID 24789723] Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients