Mechanism:

  • Rs680 (T to G or C) is a variation in an untranslated region (not in final product) of IGF-2 .
  • This leads to higher amounts of IGF-2 being made. IGF-2 is involved in growth and repair of cells (R).

The Minor "T" allele is associated with (higher IGF-2):

  • Obesity in children and adolescents (R).
  • Bad development of the placenta causing pregnancy complications (R).
  • Increased protection against stomach cancer (R).
  • Increased risk of Polycystic Ovary Syndrome (PCOS) (R).
  • Increased muscle damage after too much work (R). 
  • Dairy induced growth in height (R). 

The Major "C" allele is associated with:

  • Increased risk of type II diabetes (R)
  • Taller children (GG) (R). 
  • Higher back muscle strength (R). 
  • Polycystic Ovary Syndrome (R).

The SNP is associated with (unknown which allele):

  • Increased risk of Parkinsons Disease (R). 

rs680

Parent Gene: IGF2

Importance: 3
Less common allele: T = 30%
More common allele: C = 70%
My Genotype: Log In