Mechanism:

  • The G (minor) presumably reduces levels of APOA5 protein. Associations of APOA5 transcripts with PPARA and CPT1A1 transcripts suggest that APOA5 expression is intimately linked to hepatic lipid metabolism.

The G (minor) allele is associated with:

  • Each G=higher tryglycerides
  • AG causes 1.4x higher early heart attack risk
  • AG causes less weight gain on high fat diets
  • GG causes 2x higher early heart attack risk
  • GG causes less weight gain on high fat diets

rs662799

Parent Gene: APOA4, APOA5

Importance: 3
Less common allele: G = 16%
More common allele: A = 84%
My Genotype: Log In
Risk Allele: A, G, G, A, A, A, A

Disease/Trait: Triglyceride Measurement

The A allele of rs662799 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lipid traits (TG).

Disease/Trait: Triglyceride Measurement

The G allele of rs662799 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Triglycerides.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The G allele of rs662799 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The A allele of rs662799 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol levels (Asian initial, BMI unadjusted).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The A allele of rs662799 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol levels (Trans-ethnic initial).