The A (minor) allele is associated with:

  • Lower levels of  UCP2 protein.
  • Higher incidence of type 2 Diabetes mellitus (T2DM)
  • Increased waist circumference.
  • higher fasting insulin .
  • Lower 24-h energy expenditure.
  • More efficient energy use due to a lower degree of uncoupling, resulting in the increased ATP and ROS production.

rs660339

Parent Gene: UCP2

Importance: 3
Less common allele: A = 42%
More common allele: G = 58%
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