The "T" (minor) allele is associated with:

  • More UCP2 production and higher levels of UCP2 protein (R).
  • Lower risk of chronic inflammatory disease (such as Arthritis, MS Lupus, Crohn's, Colitis, Wegener's) (R).
  • Increased levels of HDL-Cholestrol and decreased levels of LDL-Cholestrol (in a Chinese population) (R).
  • Reduced LDL particle size levels (in a Chinese population) (R).
  • Increased energy expenditure [R].
  • Decreased lipid oxidation [R].
  • Decreased high-sensitivity Cholestrol reactive protein (hs-CRP), a biomarker of inflammation. This decrease may indicate a lower level of inflammation in the body (R).
  • Increased waist circumference (P=0.04)(R).
  • More difficulty in losing weight under a very low-calorie program (Korean women) (R) or when taking a weight loss drug (sibutramine) (R).
  • Lower insulin secretion [R].
  • Higher fasting glucose levels in the blood [R].
  • Higher risk of Diabetes (Type 2) [R].
  • Increased hardening of the arteries in women [R].
  • Increased heart disease risk [R].
  • Increased resting energy expenditure in obese children (R) and increased 24-hour energy expenditure (in Pima Indians)(R).
  • Increased weight in the Balinese urban population, but not in rural subjects with the same genotype (R).
 

rs659366

Parent Gene: UCP2

Importance: 4
Less common allele: T = 41%
More common allele: C = 59%
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