The "T" (minor) allele is associated with:
- More UCP2 production and higher levels of UCP2 protein (R).
- Lower risk of chronic inflammatory disease (such as Arthritis, MS Lupus, Crohn's, Colitis, Wegener's) (R).
- Increased levels of HDL-Cholestrol and decreased levels of LDL-Cholestrol (in a Chinese population) (R).
- Reduced LDL particle size levels (in a Chinese population) (R).
- Increased energy expenditure [R].
- Decreased lipid oxidation [R].
Decreased high-sensitivity Cholestrol reactive protein (hs-CRP), a biomarker of inflammation. This decrease may indicate a lower level of inflammation in the body (R).
- Increased waist circumference (P=0.04)(R).
- More difficulty in losing weight under a very low-calorie program (Korean women) (R) or when taking a weight loss drug (sibutramine) (R).
- Lower insulin secretion [R].
- Higher fasting glucose levels in the blood [R].
- Higher risk of Diabetes (Type 2) [R].
- Increased hardening of the arteries in women [R].
- Increased heart disease risk [R].
- Increased resting energy expenditure in obese children (R) and increased 24-hour energy expenditure (in Pima Indians)(R).
- Increased weight in the Balinese urban population, but not in rural subjects with the same genotype (R).