Mechanism:

  • Increases sensitivity of the nicotinic acetylcholine receptor (CC) [R]

  • Increases sensitivity of the nicotinic acetylcholine receptor (C) [R]

  • Maintains normal sensitivity of the nicotinic acetylcholine receptor (T) [R]

The “C” allele is associated with:

  • Increased risk for moderate to very severe chronic obstructive pulmonary disease (COPD) (CC) [R]

    This was shown in a population of this study: 406 patients with COPD and 394 healthy male subjects in a Korean population.
  • Increased risk of lung cancer (CC) [R].

  • Increased risk of nicotine dependence [R].

  • Increased risk of bladder cancer (CC and CT) [R]

The “T” allele is associated with:

  • Significantly decreased risk of COPD (TT and CT)[R].

This SNP is associated with (unknown which alleles):

  • Increased risk of heavy smoking mid-adulthood [R].

  • Influences Systolic Blood Pressure (SBP) [R].

  • Influences Body Mass Index (BMI) [R].

  • Increases risk of Lung Adenocricinoma (ADC) cancer [R].

rs6495309

Parent Gene: CHRNA3

Importance: 3
Less common allele: T = 37%
More common allele: C = 63%
My Genotype: Log In
Risk Allele: T, T

Disease/Trait: Forced Expiratory Volume

The T allele of rs6495309 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The T allele of rs6495309 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Fev/Fec Ratio

The T allele of rs6495309 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The T allele of rs6495309 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.