The Minor "G" allele is associated with:

  • Higher levels of IL-12 protein (GG).
  • Each G allele increases the risk of developing primary biliary cirrhosis (PBC) by 3.08x. PBC is a Th1 dominant condition (and Th17).

rs6441286

Parent Gene: IL12A, IL12A-AS1

Importance: 3
Less common allele: G = 38%
More common allele: T = 62%
My Genotype: Log In
Risk Allele: G, G

Disease/Trait: Biliary Liver Cirrhosis

The G allele of rs6441286 is reported to be associated with Biliary Liver Cirrhosis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Primary biliary cholangitis.

Disease/Trait: Biliary Liver Cirrhosis

The G allele of rs6441286 is reported to be associated with Biliary Liver Cirrhosis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Primary biliary cholangitis.