The Minor "A" allele is associated with:
- 4X risk of Parkinson's (with bad HO-1 SNP) (AA)
- Anxiety and Depression
- Inhibiting GSK3B in neuronal cells helps protect against oxidative stress (R).
This SNP is associated with (unknown which allele):
- GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (R).
- Oxidative stress, which works by increasing GSK3B levels, is a well-known inducer of neuronal destruction and axonal degeneration (R). Therefore, it seems like this gene will result in higher GSK3B and risk of Parkinson's, Anxiety and Depression.