The Minor "A" allele is associated with:

  • 4X risk of Parkinson's (with bad HO-1 SNP) (AA)
  • Anxiety and Depression
  • Inhibiting GSK3B in neuronal cells helps protect against oxidative stress (R).

This SNP is associated with (unknown which allele):

  • GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (R).
  • Oxidative stress, which works by increasing GSK3B levels,  is a well-known inducer of neuronal destruction and axonal degeneration (R). Therefore, it seems like this gene will result in higher GSK3B and risk of Parkinson's, Anxiety and Depression.


Parent Gene: GSK3B

Importance: 3
Less common allele: A = 41%
More common allele: G = 59%
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