rs6318 is a SNP in the HTR2C gene, which codes for the serotonin 2C receptor type. This receptor affects serotonin and dopamine activity throughout the brain, especially in the limbic system [R].

Abnormalities in this gene have been linked to various mood disorders, such as depression and bipolar disorder [R, R, R, R].

Certain variations in this gene may also increase the risk of developing alcohol use disorders in people with mood disorders [R].

This gene can also affect how people respond to pharmacological treatment with both antidepressant and antipsychotic medications (such as SSRIs and lithium , respectively) [R].

The minor ('C') allele of this SNP has also been associated with increased response to stress, as well as elevated risk of cardiovascular disease (such as coronary artery disease and heart attacks) [R].


Parent Gene: HTR2C

Importance: 5
Less common allele: C = 17%
More common allele: G = 83%
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