The A (minor) allele is associated with:

  • Reduced ability to activate receptors or cause downstream signals. This means it causes a blunted signal after activation (R). Reduced ability to activate phospholipases C and D suggests that signaling through both G(q) and G(13) pathways is hindered (R).
  • Greater mental fatigue scores (AA vs AG) (p=0.026) (R).
  • ADHD (AG) (R).
  • Better response to antidepressants/SSRIs (paxil) (AG) (R) (R).
  • Worse memory (AG) (R).
  • Tyr=A

The G (major) allele is associated with:

  • Better memory (GG) (R).
  • Higher rheumatoid arthritis risk (R).
  • His=G


Parent Gene: HTR2A

Importance: 4
Less common allele: A = 8%
More common allele: G = 92%
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