Mechanism: functional polymorphism in the promotor region of the serotonin receptor gene C/T(102) . The two variants (rs6311 and rs6313) are in complete LD. Each G allele of rs6313 is shown to be associated with lower mRNA and lower protein expression than the A variant (R).

The A (minor) allele is associated with:

  • Increased somatization in Fibromyalgia subjects (AA) (R).
  • Lower general health and social function scores (A) (p=0.00320.034)(R).

The G (major) allele is associated with:

  • Increased number of psychosomatic symptoms (R).
  • Increased risk of Fibromyalgia (R), CFS (R) and Temporomandibular joint disorder (R).
  • Suicide attempt (GG) (R).
  • Higher extraversion personality scores among borderline personality disorder patients and the presence of visual and auditory hallucinations in patients with late-onset Alzheimer's Disease (R).
  • Worsened working memory in Schizophrenia (GG vs an A allele) (R).
  • Increased risk of irritable bowel syndrome (R).

rs6313

Parent Gene: HTR2A

Importance: 5
Less common allele: A = 44%
More common allele: G = 56%
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