rs6123837 ( G(-1211)A ) is a SNP within GNAS (GNAS complex locus - encoding the Gs alpha subunit).

[PMID 18192900] among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...

  • those with GG genotypes lost significantly more weight compared to A allele carriers
  • sibutramine was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure

[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight .

[PMID 23065660] GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.


Parent Gene: GNAS

Importance: 1
Less common allele: A = 41%
More common allele: G = 59%
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