rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).

In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538]


[PMID 24264314] Association between CCND1 and XPC polymorphisms and bladder cancer risk: a meta-analysis based on 15 case-control studies

rs603965

Parent Gene: CCND1

Importance: 2
Less common allele: A = 41%
More common allele: G = 59%
My Genotype: Log In
Risk Allele: G, G

Disease/Trait: Multiple Myeloma

The G allele of rs603965 is reported to be associated with Multiple Myeloma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Multiple myeloma (IgH translocation) (t11;14 vs. controls).

Disease/Trait: Multiple Myeloma

The G allele of rs603965 is reported to be associated with Multiple Myeloma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Multiple myeloma (IgH translocation) (t11;14 vs non t11;14).