rs60369023 is a SNP of the CDA gene. Cytidine deaminase (CDA) is a key enzyme in the metabolism of Ara-C (cytosine arabinoside), hence SNPs of this gene contribute to the susceptibility to Ara-C.

Note: The cytosine arabinoside (Ara-C)-based chemotherapy is the major remedial measure for acute myeloid leukemia (AML).

The ''GA'' genotype significantly improved Ara-C-based chemotherapy response in patients with acute myeloid leukemia (OR = 9.851; P = 0.0263) [R].



Parent Gene: CDA

Importance: 2
Less common allele: A = 0%
More common allele: G = 100%
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