Heterozygosity increased the risk of age-related macular degeneration (AMD) compared to the GG genotypes in the French study population (odds ratio (OR) = 3.5, p<0.01) [R].

Male AA genotype carriers (25-74 years) had significantly higher total cholesterol and triglyceride concentrations (5.70 mmol/l vs. 5.49 mmol/l; p = 0.036, and 1.70 mmol/l vs. 1.40 mmol/l, p = 0.023, respectively) than GA carriers and the oldest males (65-74 years) AA carriers had significantly higher high density lipoprotein cholesterol concentrations in comparison to heterozygous (1.52 mmol/l vs. 1.36 mmol/l, p = 0.033) [R].

The subjects with AA genotype had high risk of coronary artery disease (CAD) (OR = 1.76, P = 0.038 for AA vs. GG; and OR = 1.75, P = 0.036 for AA vs. GG/GA) [R].

The ''A'' allele as compared to ''G'' allele was associated with increased odds of premature coronary artery disease (PCAD) in total population (adjusted OR = 1.3, p = 0.020), and in women (adjusted OR = 1.3, p = 0.037), but not in men (adjusted OR = 1.2, p = 0.311) [R].

 

rs5888

Parent Gene: SCARB1

Importance: 2
Less common allele: A = 32%
More common allele: G = 68%
My Genotype: Log In