Mechanisms:

  • A = High CETP activity

  • G = Low CETP activity [R]

The “A” allele is associated with:

  • Decreased risk of early-onset myocardial infarction (men) [R]

  • High levels of serum HDL concentrations in adolescents [R]

The “G” allele is associated with:

  • High HDL levels [R]

  • Decreased risk of Alzheimer’s disease and dementia, as well as slower rate of memory decline [R]

  • Increased risk of myocardial infarction (men) [R]

  • Increased risk for polypoidal choroidal vasculopathy (PCV) (Chinese Han) [R]

  • Structure of white matter in the brain [R]

  • Lower triglyceride concentrations [R]

This SNP is associated with (unknown which alleles):

  • Gain in abdominal visceral fat (in response to overfeeding) [R]

  • Longevity [R]

  • Lipid metabolism [R]

  • Low levels of small, dense LDL (Indian) [R]

  • Increased risk for gray matter abnormalities in the posterior brain (healthy, older adults)  [R]

rs5882

Parent Gene: CETP

Importance: 5
Less common allele: G = 47%
More common allele: A = 53%
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