The Minor "G" allele is associated with:
- higher risk for nicotine dependence and lung cancer (GG) (R).
- higher nicotine intake levels compared to non-smokers (R).
- higher likelihood of being a heavy smoker, with GG smoking 3.6 more cigarettes per day than AA (R).
- increased risk of developing multiple primary cancers (R).
- more pleasure, reward, and motivation from cigarettes (GG vs AA) (R).