The Minor "G" allele is associated with:

  • higher risk for nicotine dependence and lung cancer (GG) (R).
  • higher nicotine intake levels compared to non-smokers (R).
  • higher likelihood of being a heavy smoker, with GG smoking 3.6 more cigarettes per day than AA (R).
  • increased risk of developing multiple primary cancers (R).
  • more pleasure, reward, and motivation from cigarettes (GG vs AA) (R).

rs578776

Parent Gene: CHRNA3

Importance: 3
Less common allele: G = 44%
More common allele: A = 56%
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