rs5746059 is a SNP in the tumor necrosis factor-alpha receptor 2 TNFRSF1B gene.

A study of ~1,800 subjects from 400 Caucasian families concluded that carriers of a rs5746059(A) allele had a 4.6% higher fat mass and a 2.5% increased percentage fat mass compared to noncarriers; the results were significant after multiple testing correction. This same correlation was also seen in 700 independent Chinese Han adults and 1,000 additional Caucasians. This SNP therefore appears to be associated with risk for obesity .[PMID 18685868]

[PMID 20217072] SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.


Parent Gene: TNFRSF1B

Importance: 1
Less common allele: G = 14%
More common allele: A = 86%
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