The ''T'' allele showed a significant association with chronic obstructive pulmonary disease (COPD) when compared with controls (T allele: p < 0.0001) [R].

The ''T'' allele might increase the susceptibility to cervical cancer [R].

Heterozygous allele carriers might have decreased risks of Graves' disease (GD) when compared with the homozygote carriers (TT+TC vs. CC: OR = 0.78) [R].

The ''C'' allele was associated with rheumatoid arthritis [R].

CT genotype and T allele were associated with an increased risk for brucellosis (TT genotype; OR = 2.544, P = 0.002) [R].

Subjects with CA haplotype had a 1.37-fold increased risk to develop Ewing's sarcoma (ES) (p=0.032) [R]. 

The ''T'' allele added up to the risk of hepatitis C virus (HCV) infection chronicity significantly in patients with the presence of HCV F protein (adjusted OR=2.698, P=0.003). While CC genotype, along with the presence of HCV F protein, indicated a significantly higher CTLA-4 level than that in anti-HCV F antibody negative patients [R]. 


Parent Gene: CTLA4

Importance: 2
Less common allele: T = 5%
More common allele: C = 95%
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