- Higher levels of BDNF than A (increased transcription) (GG) [R].
- Increased BDNF (G)
- Lower BDNF production through altered mRNA folding and splicing (A) [R,R2].
The "A" (minor) allele is associated with:
- higher risk for multiple sclerosis (in the Polish population) [R].
- increased risk of schizophrenia (in east Asian subjects)[R].
- higher risk of hallucinations in Alzheimer's patients [R].
The "G" (major) allele is associated with:
- higher risk of anorexia nervosa and bulimia [R,R2].
- increased risk of ADHD and learning disabilities in children [R].
- higher risk for asthma (in Chinese Han children) [R].
This SNP is associated with (unknown which alleles):
- Alcohol and substance abuse [R].