rs549908 is a SNP of the IL18  gene. It may be a risk factor for the development of alopecia areata (AA).

Note: Alopecia areata also known as ''spot baldness'' is an autoimmune disease in which hair is lost from some or all parts of the body usually the scalp. 

The ''T'' allele frequency (89.9) was higher in the alopecia areata (AA) group compared with (84.6%) the control group in a korean population [R].

rs549908 (no reported alleles) has been associated with pulmonary tuberculosis (TB) [R]. 

The ''TT'' genotype variant can contribute to renal manifestations in patients with Systemic lupus erythematosus (SLE) (OR = 3.360 ;P = 0.0039) [R].

A significantly higher ''T'' allele frequency was seen in systemic lupus erythematosus (SLE0 patients (P = 0.003; OR = 1.97) and a significantly higher ''T'' allele frequency was seen in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18) [R].

The frequency of the ''G'' allele was significantly higher in the patient group (13.9%) with Kawasaki disease (KD) than in the control group (2.7%; P<0.0001, OR=5.93). Therefore, persons with the C allele may have higher risk of developing KD [R]. 

T>G polymorphism showed a protective effect against spastic cerebral palsy (CP) [R].


Parent Gene: IL18

Importance: 2
Less common allele: G = 22%
More common allele: T = 78%
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