rs5491 is a SNP of the ICAM1 gene. It is strongly associated with soluble Intercellular adhesion molecule-1 (sICAM-1) levels.

rs5491 (no reported alleles) had a significant association with metabolic syndrome (MetS) (P = .005) [R].

The ''T''allele was associated with 50% lower sICAM-1 (soluble Intercellular adhesion molecule-1) levels, a subclinical marker for atherosclerosis [RR1].

Patients with oral cancer who had at least 1 ''T'' allele were at lower risk of developing an advanced clinical stage (III/IV) (p<0.05), compared to those patients with AA homozygotes [R]. 

The risk of asthma was higher for children carrying the AT or TT genotypes (OR= 1.68) than for those with the AA genotypes [R]


Parent Gene: ICAM1

Importance: 2
Less common allele: T = 8%
More common allele: A = 92%
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