rs5491 is a SNP of the ICAM1 gene. It is strongly associated with soluble Intercellular adhesion molecule-1 (sICAM-1) levels.
rs5491 (no reported alleles) had a significant association with metabolic syndrome (MetS) (P = .005) [R].
Patients with oral cancer who had at least 1 ''T'' allele were at lower risk of developing an advanced clinical stage (III/IV) (p<0.05), compared to those patients with AA homozygotes [R].
The risk of asthma was higher for children carrying the AT or TT genotypes (OR= 1.68) than for those with the AA genotypes [R]