rs5370 is a SNP of the EDN1 gene, which encodes a potent vasoconstrictor Endothelin-1 (ET-1). It is significantly associated with HDL cholesterol values in women, but not in men  (P=1.3×10-5).

The minor allele ''T'' was associated with a with lower HDL (High-density lipoprotein) cholesterol values (P=.0007) [R].

Rheumatoid arthritis (RA) patients with the TT genotype had a three fold increased risk of being hypertensive when compared to GG homozygotes (OR = 2.89) [R].

Compared to wild-type homozygotes (GG), heterozygotes and mutant homozygotes (GT/TT) showed a positive association with hearing impairment in the elderly [R].

"T" allele appeared to be associated with disease progression in patients with Primary biliary cirrhosis (PBC) [R]. 

The minor allele ''T'' was associated with higher risk of hypertension (odds ratio: 1.95; P=0.0003) [R].

''GT'' genotype is associated with plasma cholesterol in primary nephrotic syndrome (NS) patients (P<0.05) [R].


Parent Gene: EDN1

Importance: 4
Less common allele: T = 25%
More common allele: G = 75%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Vasoactive Peptide Measurement

The T allele of rs5370 is reported to be associated with Vasoactive Peptide Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Circulating vasoactive peptide levels (ET).