rs5335, a SNP in the EDNRA gene, has been associated with a (slightly) increased risk for hypertension, based on a study of ~1400 Caucasians. The odds ratio per (G) allele is 1.19 (CI: 1.00-1.41, p=0.05).[PMID 18172451]


[PMID 20028935] EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates and cystic fibrosis pulmonary disease severity

[PMID 20964792] A role for endothelin receptor type A in migraine without aura susceptibility? A study in Portuguese patients.


[PMID 23206929] Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population


[PMID 26178354] [Association between genetic polymorphisms of EDNRA gene and high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau]

rs5335

Parent Gene: EDNRA

Importance: 1
Less common allele: G = 42%
More common allele: C = 58%
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