An association was found between Systemic lupus erythematosus (SLE) and rs5029939 (meta-analysis p = 2.89 x 10(-12), odds ratio 2.29).[PMID 18677312]

[PMID 19387456] Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations

[PMID 20511617] Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population

[PMID 21740805] Variants of tumor necrosis factor-induced protein 3 gene are associated with left ventricular hypertrophy in hypertensive patients

[PMID 19169254] Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19849816] Genetics of rheumatic disease.

[PMID 20617138] Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.

[PMID 22488580] Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity.

[PMID 22924496] Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.

[PMID 25806576] The polymorphisms of tumor necrosis factor-induced protein 3 gene may contribute to the susceptibility of chronic primary immune thrombocytopenia in Chinese population

[PMID 26092158] IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

[PMID 25337792] Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population


Parent Gene: TNFAIP3

Importance: 3
Less common allele: G = 14%
More common allele: C = 86%
My Genotype: Log In
Risk Allele: G

Disease/Trait: Systemic Lupus Erythematosus

rs5029939 is associated with Systemic Lupus Erythematosus (R) . It is reported to increased association with Systemic lupus erythematosus. No specific risk allele was identified in the study.

Disease/Trait: Sjogren Syndrome

The G allele of rs5029939 is reported to be associated with Sjogren Syndrome (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sjögren's syndrome.