The A (major) allele is associated with

  • AA/AG had an increased immune response (increase in IL-4 levels) to measles vaccine.

G (minor) allele is associated with:

  • Lower risk of heart attacks.
  • Higher blood pH.
  • 10X higher levels of certain bacteria.
  • Worse asthma.
  • Increased risk of septic shock (body attacks itself during infection).
  • Increased risk of Gram-negative bacterial infections.


Parent Gene: TLR4

Importance: 3
Less common allele: G = 6%
More common allele: A = 94%
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